Opportunities Unlimited of Niagara receives funding from various sources, such as:
| NYS Office of Mental Retardation and Developmental Disabilities (OMRDD) | |
| NYS Office of Vocational and Educational Services for Individuals with Disabilities | |
| Medicaid | |
| Eastern Niagara United Way; United Way of Niagara; and United Way of the Tonawandas | |
| Income from sheltered workshop contracts | |
| Grants | |
| Charitable contributions through the Opportunities Unlimited of Niagara Foundation |